Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

Around 95% of patients diagnosed with pancreatic cancer will die of their disease within 5
years, three quarters within a year. The major hurdle in improving prognosis is the lack of a …

Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide. Increasing
evidence has confirmed the pivotal role of stromal components in the regulation of …

Recent studies have shed new light on the contribution of the pancreatic cancer
fibroinflammatory stroma to pancreatic cancer biology. Additional studies are needed to …

Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by
a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. The DR is …

Recent studies have demonstrated that the interaction between the cancer and the stroma,
play a key role in the development of pancreatic cancer. The desmoplasia, which consists of …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …