Highlights•Antiplatelet agents play a key role in the therapy of acute coronary syndromes
(ACS).•P2Y 12 antagonists inhibit processes important for both thrombosis and …

P2Y 12 receptor is a 342 amino acid Gi-coupled receptor predominantly expressed on
platelets. P2Y 12 receptor is physiologically activated by ADP and inhibits adenyl cyclase …

The P2Y12 receptor for adenosine diphosphate (ADP) plays a central role in the
physiological process of hemostasis and thrombosis. It has proven to be a key target in the …

Atherothrombosis is an acute complication that develops on the surface of a ruptured
atheromatous plaque or as a consequence of endothelial erosion that may cause …

Platelets express a wide range of receptors and proteins that play essential roles in
thrombus formation. Among these, the P2Y 12 receptor, a member of the G protein-coupled …

Platelet P2Y12 inhibitors have become a central component of the treatment strategy for
patients with atherothrombosis due to the importance of platelet P2Y12 receptors in arterial …

The platelet P2Y12 receptor (P2Y12R) for adenosine 5′ diphosphate (ADP) plays a central
role in platelet function, hemostasis, and thrombosis. Patients with inherited P2Y12R defects …

The platelet P2Y 12 receptor is involved in all aspects of arterial thrombosis, including
adhesion, activation, aggregation, secretion and development of a stable aggregate on …

Background Thrombus formation is the result of the disruption of the complex homeostatic
system involving platelets, coagulation factors, inflammatory elements, cytokines, and the …

Introduction: P2Y12 inhibitors are a critical component of dual antiplatelet therapy (DAPT),
which is the superior strategy to prevent arterialthrombosis in patients with acute coronary …