Inhibition of NAALADase by 2‐PMPA attenuates cocaine‐induced relapse in rats: a NAAG‐mGluR2/3‐mediated mechanism
ZX Xi, X Li, XQ Peng, J Li, L Chun… - Journal of …, 2010 - Wiley Online Library
Pharmacological activation of group II metabotropic glutamate receptors (mGluR2/3) inhibits
cocaine self‐administration and reinstatement of drug‐seeking behavior, suggesting a …
cocaine self‐administration and reinstatement of drug‐seeking behavior, suggesting a …
Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats
XQ Peng, J Li, EL Gardner, CR Ashby Jr… - European journal of …, 2010 - Elsevier
We have recently reported that the endogenous mGlu2/3 agonist N-acetylaspartylglutamate
(NAAG) and the N-acetylated-α-linked-acidic dipepetidase (NAALADase, a NAAG …
(NAAG) and the N-acetylated-α-linked-acidic dipepetidase (NAALADase, a NAAG …
Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate …
C Hicks, RA Gregg, SU Nayak, LA Cannella… - …, 2017 - Springer
Rationale Metabotropic glutamate 2 and 3 (mGluR2/3) receptors are implicated in drug
addiction as they limit excessive glutamate release during relapse. N …
addiction as they limit excessive glutamate release during relapse. N …
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine-and food-seeking behavior in rats
J Peters, PW Kalivas - Psychopharmacology, 2006 - Springer
Rationale Group II metabotropic glutamate receptor (mGluR2/3) agonists are proposed to
serve as potential treatment for addiction. Objectives The present study examined the …
serve as potential treatment for addiction. Objectives The present study examined the …
N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats
Pharmacological activation of group II metabotropic glutamate (mGlu2 and mGlu3) receptors
inhibits reward-seeking behavior and/or rewarding efficacy induced by drugs (cocaine …
inhibits reward-seeking behavior and/or rewarding efficacy induced by drugs (cocaine …
Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) …
Inhibition of glutamate carboxypeptidase II (GCP II; NAALADase) produces a variety of
effects on glutamatergic neurotransmission. The aim of this study was to investigate effects …
effects on glutamatergic neurotransmission. The aim of this study was to investigate effects …
Activation of mGluR7s inhibits cocaine‐induced reinstatement of drug‐seeking behavior by a nucleus accumbens glutamate‐mGluR2/3 mechanism in rats
X Li, J Li, EL Gardner, ZX Xi - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 114, 1368–1380. Abstract The metabotropic glutamate receptor 7
(mGluR7) has been reported to be involved in cocaine and alcohol self‐administration …
(mGluR7) has been reported to be involved in cocaine and alcohol self‐administration …
Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys
RM Bauzo, HL Kimmel, LL Howell - Pharmacology Biochemistry and …, 2009 - Elsevier
Recent evidence indicates that group II metabotropic glutamate receptors (mGluR2 and
mGluR3) may play a role in the pathology of cocaine addiction. The purpose of the current …
mGluR3) may play a role in the pathology of cocaine addiction. The purpose of the current …
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming-and cue-induced reinstatement of cocaine seeking
V Kumaresan, M Yuan, J Yee, KR Famous… - Behavioural brain …, 2009 - Elsevier
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …
Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison …
B Lee, DM Platt, JK Rowlett, AS Adewale… - … of Pharmacology and …, 2005 - ASPET
Growing evidence suggests a role for metabotropic glutamate receptors (mGluRs) in the
behavioral effects of cocaine related to its abuse. The mGluR5 subtype, in particular, has …
behavioral effects of cocaine related to its abuse. The mGluR5 subtype, in particular, has …