Importance of the field: Fas receptor is a mediator of the external apoptotic pathway in many
cells and tissues. It is proposed that Fas receptor mediates osteoresorptive effects of …

Bone mass is determined by bone cell differentiation, activity, and death, which mainly occur
through apoptosis. Apoptosis can be triggered by death receptor Fas (CD95), expressed on …

The treatment of osteoporosis has been a critical issue in today's medical situation. Various
therapeutic agents and strategies have been investigated and applied, and have proven …

Both the number and the activity of osteoclasts are critical for maintaining normal bone
turnover. The number is determined by rates of cell differentiation and death. Fas-mediated …

One of the pivotal factors in the health and maintenance of dense bone is the coordinated
activity of osteoblasts and osteoclasts. Research scientists are developing an enormous …

The interplay between osteoblasts and osteoclasts has a crucial role in maintaining bone
homeostasis. In this study, we reveal that osteoblasts are capable of inducing osteoclast …

We investigated the cellular and humoral interactions between peripheral blood
mononuclear cells (PBMCs) and human osteoblasts, leading to apoptosis of osteoblasts …

Abstract Fas ligand (FasL, CD178) belongs to classical apoptotic molecules, however,
recent evidence expands the spectrum of FasL functions into non-apoptotic processes which …

We incidentally found that osteoclast precursors and mature osteoclasts express Fas ligand
(FasL) as well as Fas, which was confirmed by flow cytometry, immunofluorescent staining …

During bone development, FasL acts not only through the traditional apoptotic mechanism
regulating the amount of bone-resorbing osteoclasts, but there is also growing evidence …