In the mid-1970s, an intense race to identify endogenous substances that activated the
same receptors as opiates resulted in the identification of the first endogenous opioid …

Opioids are involved in the physiological control of numerous functions of the central
nervous system, particularly nociception. It appears that some endogenous neuropeptides …

All endogenous opioid peptides isolated belong to one of three peptide families, each
deriving from a distinct precursor molecule: pro-opiomelanocortin is the common precursor …

Since the discovery of the enkephalins in 1975, an increasing number of larger opioid
peptides, which contain the sequence of either met-enkephalin or leuн enkephalin at their N …

The discovery of endogenous opioid peptides 25 years ago opened up a new chapter in
efforts to understand the origins and control of pain, its relationships to other biological …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Opioids, such as morphine and fentanyl, are widely used for the treatment of severe pain;
however, prolonged treatment with these drugs leads to the development of tolerance and …