Angiogenesis plays a critical role in embryo development, tissue repair, tumor growth and
wound healing. In the present study, we investigated the role of the serine/threonine kinase …

Previous in vivo and in vitro studies have shown that Akt1 serves as a crucial regulator of
vascular maturation, extracellular matrix composition, and angiogenesis in tumors. Hence …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1∆ SMC) but
not in Akt2∆ SMC mice. The proliferation of ECs, recruitment of pericytes, and coverage of …

Akt, or protein kinase B, is a multifunctional serine-threonine protein kinase implicated in a
diverse range of cellular functions including cell metabolism, survival, migration, and gene …

Regulation of endothelial cell apoptosis is a critical modulator of normal and pathological
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in …

Although numerous studies have implicated Akt and Src kinases in vascular endothelial
growth factor (VEGF) and Angiopoietin‐1 (Ang‐1)‐induced endothelial‐barrier regulation, a …

In this study, we investigated the role of Akt1 isoform in phenotypic change of vascular
smooth muscle cells (VSMCs) and neointima formation. Laminin-induced conversion of …

Proteus syndrome is a progressive overgrowth disorder with vascular malformations caused
by mosaic expression of the AKT1 c. 49G> A, p.(E17K) activating variant which was …

The formation of new blood vessels by sprouting angiogenesis is tightly regulated by
contextual cues that affect angiogeneic growth factor signaling. Both constitutive activation …