Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk …

CH Diep, LJ Mauro, CA Lange - Steroids, 2023 - Elsevier
Progesterone and progestin agonists are potent steroid hormones. There are at least three
major types of progesterone receptor (PR) families that interact with and respond to …

Reply to Is progesterone a neutral or protective factor for breast cancer?

C Brisken - Nature Reviews Cancer, 2014 - nature.com
I am grateful for the comments on my Review article (Progesterone signalling in breast
cancer: a neglected hormone coming into the limelight. Nature Rev. Cancer 13, 385–396 …

90 years of progesterone: progesterone and progesterone receptors in breast cancer: past, present, future

KB Horwitz, CA Sartorius - Journal of molecular …, 2020 - jme.bioscientifica.com
Progesterone and progesterone receptors (PR) have a storied albeit controversial history in
breast cancers. As endocrine therapies for breast cancer progressed through the twentieth …

Challenges to defining a role for progesterone in breast cancer

CA Lange - steroids, 2008 - Elsevier
Progesterone is an ovarian steroid hormone that is essential for normal breast development
during puberty and in preparation for lactation. The actions of progesterone are primarily …

Exogenous Hormones and Breast Cancer Risk: Contraception, Menopausal Hormone Therapy, and Breast Cancer Survivors

MD Pearlman - Clinical Obstetrics and Gynecology, 2022 - journals.lww.com
The use of exogenous estrogen and progesterone/progestin medications spans the
reproductive and postreproductive lives of millions of women providing control over …

Aspects of progesterone receptor (PR) activity regulation-impact on breast cancer progression

D Piasecka, AC Składanowski, R Kordek… - Postepy …, 2015 - europepmc.org
Progesterone receptor (PR) and its specific ligand play a key role in development and
physiology of mammary gland. The role of PR in initiation and progression of breast …

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

EL Dolan, R Safi, C Chang, HE Eaton, S Krishnan… - bioRxiv, 2023 - biorxiv.org
The steroid hormone progesterone, acting through its nuclear progesterone receptor (PR),
has complex physiologic activities with different levels of hormones manifesting distinct and …

Progesterone and overlooked endocrine pathways in breast cancer pathogenesis

C Brisken, K Hess, R Jeitziner - Endocrinology, 2015 - academic.oup.com
Worldwide, breast cancer incidence has been increasing for decades. Exposure to
reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk …

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

C Brisken - Nature Reviews Cancer, 2013 - nature.com
Understanding the biology of the breast and how ovarian hormones impinge on it is key to
rational new approaches in breast cancer prevention and therapy. Because of the success …

Progesterone action in breast, uterine, and ovarian cancers

CH Diep, AR Daniel, LJ Mauro… - Journal of …, 2015 - jme.bioscientifica.com
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …