Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome
maintenance and proper cell division in animals and plants. A major function of TLKs is to …

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to
restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this …

Tousled-like kinases (TLKs) constitute a family of serine/threonine kinases conserved in
plants and animals that act in a cell cycle-dependent manner. In mammals, their activity …

Abstract Background The Tousled Like Kinases (TLKs) are involved in chromatin dynamics,
including DNA replication and repair, transcription, and chromosome segregation. Indeed …

Histone chaperones are at the hub of a diverse interaction networks integrating a plethora of
chromatin modifying activities. Histone H3/H4 chaperone ASF1 is a target for cell-cycle …

Abstract The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–
threonine kinases that have been implicated in DNA replication, DNA repair, transcription …

First described in Arabidopsis thaliana [1], Tousled-like kinases (Tlks) are highly conserved
in both plants and animals. In plants, Tousled kinase is essential for proper flower and leaf …

The regulation of chromatin structure is critical for a wide range of essential cellular
processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 …

Tousled-like kinases (TLKs) are required for genome stability and normal development in
numerous organisms and have been implicated in breast cancer and intellectual disability …

The Tousled-like kinases (TLKs) function in processes of chromatin assembly, including
replication, transcription, repair, and chromosome segregation. TLKs interact specifically …