Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Germinal centers (GCs) are essential structures of the humoral immune response, which
form in the periphery in response to T cell dependent antigens. During the GC reaction, B …

B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

The immune system requires the production of high affinity antibodies of different subclasses
to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

One of the unusual features of germinal center (GC) B cells is that they manifest many
hallmarks of cancer cells. Accordingly, most B‐cell neoplasms originate from the GC …

In response to T cell–dependent antigens, mature B cells are stimulated to form germinal
centers (GCs), the sites of B cell affinity maturation and the cell of origin (COO) of most B cell …

Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of
immunization. They arise in about 1 week and can persist for several months. In GC s, B …

The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is
targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that …