Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy

MA Dale, MK Ruhlman, BT Baxter - … , thrombosis, and vascular …, 2015 - Am Heart Assoc
Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell
infiltration. AAA is typically an asymptomatic disease and caused≈ 15 000 deaths annually …

Inflammation in abdominal aortic aneurysms: cellular infiltrate and cytokine profiles

MJ Eagleton - Vascular, 2012 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) pathogenesis occurs as a result of the altered
homeostasis of the aortic vessel wall structural proteins. This results in weakening, and …

Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Monocytes and macrophages in abdominal aortic aneurysm

J Raffort, F Lareyre, M Clément… - Nature Reviews …, 2017 - nature.com
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Abdominal aortic aneurysms: an autoimmune disease?

VP Jagadesham, DJA Scott, SR Carding - Trends in molecular medicine, 2008 - cell.com
Abdominal aortic aneurysms (AAAs) are a multifactorial degenerative vascular disorder. One
of the defining features of the pathophysiology of aneurysmal disease is inflammation …

Inflammation and cellular immune responses in abdominal aortic aneurysms

K Shimizu, RN Mitchell, P Libby - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
Expansion and rupture of abdominal aortic aneurysms (AAA) result in high morbidity and
mortality rates. Like stenotic atherosclerotic lesions, AAA accumulate inflammatory cells, but …

Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm—brief report

H Yang, T Zhou, A Stranz, E DeRoo… - … , thrombosis, and vascular …, 2021 - Am Heart Assoc
Objective: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …

Modulation of immune‐inflammatory responses in abdominal aortic aneurysm: Emerging molecular targets

H Li, S Bai, Q Ao, X Wang, X Tian, X Li… - Journal of …, 2018 - Wiley Online Library
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity

A Sagan, TP Mikolajczyk, W Mrowiecki… - Frontiers in …, 2019 - frontiersin.org
Abdominal Aortic Aneurysm (AAA) is a major cause of cardiovascular mortality. Adverse
changes in vascular phenotype act in concert with chronic inflammation to promote AAA …