Type 1 Diabetes Mellitus (T1DM), also known as insulin-depended diabetes mellitus
(IDDM), is an autoimmune disorder, characterised by the destruction of insulin-producing β …

Abstract Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing
beta cells in the pancreas. Prevention of T1D will require the ability to detect and modulate …

Human leukocyte antigen (HLA) is widely recognized to influence individual Type 1 diabetes
(T1D) risk. Here we utilized an immunogenetic epidemiological approach to evaluate the …

Type 1 diabetes (T1D) is a complex, autoimmune disease with a strong heritable
component. The single most important genomic region for this and a large number of other …

Type I diabetes mellitus (T1DM) is an organ‐specific autoimmune disorder affecting the
insulin‐producing pancreatic cells. T1DM genetic association studies have so far revealed …

Aims/hypothesis The study aimed to assess, in multiple populations, the role of HLA alleles
on early and late age at onset of type 1 diabetes. Methods Stepwise linear regression …

It has been more than 30years since the first evidence was published suggesting the
involvement of a specific chromosomal region, HLA, in modulating the risk for type 1 …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune
mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA …

Background: Type 1 diabetes is an autoimmune disease characterized by insulin deficiency
due to pancreatic islet beta cell function loss, resulting in increased blood glucose levels …

With recent advances in immunogenetics, susceptibility to insulindependent diabetes
mellitus (IDDM) is now being evaluated at the molecular level, focusing primarily on HLA-DQ …