Parasite proteins exported to the surface of Plasmodium falciparum-parasitized red blood
cells (pRBCs) have a major role in severe malaria clinical manifestation, where pRBC …

One of the most important factors behind resistance evolution in malaria is the failure to
deliver sufficiently high amounts of drugs to early stages of Plasmodium-infected red blood …

Current administration methods of antimalarial drugs deliver the free compound in the blood
stream, where it can be unspecifically taken up by all cells, and not only by Plasmodium …

Most drugs currently entering the clinical pipeline for severe malaria therapeutics are of
lipophilic nature, with a relatively poor solubility in plasma and large biodistribution volumes …

Abstract Background Rosette-formation of Plasmodium falciparum parasitized erythrocytes
is of importance in the development of severe malaria. The parasite-derived molecule …

Paul Ehrlich's dream of a'magic bullet'that would specifically destroy invading microbes is
now a major aspect of clinical medicine. However, a century later, the implementation of this …

The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs,
targeting molecules, or encapsulating structures is a strategy that can provide new …

Malaria is an infectious disease that needs to be addressed using innovative approaches to
counteract spread of drug resistance and to establish or optimize vaccination strategies …

Combination therapies, where two drugs acting through different mechanisms are
administered simultaneously, are one of the most efficient approaches currently used to treat …

The fight against most infectious diseases, including malaria, is often hampered by the
emergence of drug resistance and lack or limited efficacies of vaccines. Therefore, new …