[HTML][HTML] Emerging cytotoxic alkaloids in the battle against cancer: Overview of molecular mechanisms

Z Habli, G Toumieh, M Fatfat, ON Rahal… - Molecules, 2017 - mdpi.com
Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

[PDF][PDF] Alkaloids-important therapeutic secondary metabolites of plant origin

R Kaur, S Arora - J Crit Rev, 2015 - e-tarjome.com
Plants are eminent source of new therapeutic agents that helps to alleviate human ailments
and promote health. The noteworthy preventive and protective properties of these …

[HTML][HTML] Update and new insights on future cancer drug candidates from plant-based alkaloids

M Tilaoui, H Ait Mouse, A Zyad - Frontiers in Pharmacology, 2021 - frontiersin.org
Cancer is a complex multifactorial disease that results from alterations in many physiological
and biochemical functions. Over the last few decades, it has become clear that cancer cells …

Alkaloids for cancer prevention and therapy: Current progress and future perspectives

A Mondal, A Gandhi, C Fimognari, AG Atanasov… - European journal of …, 2019 - Elsevier
Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

[HTML][HTML] Anticancer alkaloids from trees: Development into drugs

T Isah - Pharmacognosy reviews, 2016 - ncbi.nlm.nih.gov
Trees have made an enormous phytochemical contribution in anticancer drugs'
development more than any other life form. The contributions include alkaloids that are …

Plants in anticancer drug discovery: from molecular mechanism to chemoprevention

AJ Siddiqui, S Jahan, R Singh, J Saxena… - BioMed Research …, 2022 - Wiley Online Library
Cancer is one of the primary causes of mortality globally, and the discovery of new
anticancer drugs is the most important need in recent times. Natural products have been …

Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

T Efferth, F Oesch - Seminars in Cancer Biology, 2021 - Elsevier
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

[HTML][HTML] Diversity in chemical structures and biological properties of plant alkaloids

S Bhambhani, KR Kondhare, AP Giri - Molecules, 2021 - mdpi.com
Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …

[HTML][HTML] Therapeutic role of alkaloids and alkaloid derivatives in cancer management

K Olofinsan, H Abrahamse, BP George - Molecules, 2023 - mdpi.com
Cancer is a neoplastic disease that remains a global challenge with a reported prevalence
that is increasing annually. Though existing drugs can be applied as single or combined …

Role of plants in anticancer drug discovery

J Khazir, BA Mir, L Pilcher, DL Riley - Phytochemistry letters, 2014 - Elsevier
Cancer is one of the major causes of death and the number of new cases, as well as the
number of individuals living with cancer, is expanding continuously. Worldwide the alarming …