Na/K pump and beyond: Na/K-ATPase as a modulator of apoptosis and autophagy
C Felippe Gonçalves-de-Albuquerque, A Ribeiro Silva… - Molecules, 2017 - mdpi.com
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as
a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon …
a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon …
Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells
Z Li, Z Zhang, JX Xie, X Li, J Tian, T Cai, H Cui… - Journal of Biological …, 2011 - ASBMB
Cells contain a large pool of nonpumping Na/K-ATPase that participates in signal
transduction. Here, we show that the expression of α1 Na/K-ATPase is significantly reduced …
transduction. Here, we show that the expression of α1 Na/K-ATPase is significantly reduced …
Modulators of Na/K-ATPase: a patent review
HYL Wang, GA O'Doherty - Expert Opinion on Therapeutic Patents, 2012 - Taylor & Francis
Introduction: Na/K-ATPase is a heterodimeric transmembrane protein that regulates
neuronal signaling, ion homeostasis, muscle contraction and substrate transportation …
neuronal signaling, ion homeostasis, muscle contraction and substrate transportation …
Na, K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer
TP Huynh, V Mah, VB Sampson… - … of Physiology-Lung …, 2012 - journals.physiology.org
Diminished Na, K-ATPase expression has been reported in several carcinomas and has
been linked to tumor progression. However, few studies have determined whether Na, K …
been linked to tumor progression. However, few studies have determined whether Na, K …
Na+/K+-ATPase and Cancer
T Mijatovic, F Dufrasne, R Kiss - Pharmaceutical patent analyst, 2012 - Taylor & Francis
The sodium pump, Na+/K+-ATPase, could be an important target for the development of
anticancer drugs as it serves as a versatile signal transducer, plays a key role in cell …
anticancer drugs as it serves as a versatile signal transducer, plays a key role in cell …
Na+/K+-ATPase α subunits as new targets in anticancer therapy
T Mijatovic, L Ingrassia, V Facchini… - Expert opinion on …, 2008 - Taylor & Francis
Background: The sodium pump (Na+/K+-ATPase) could be a target for the development of
anticancer drugs as it serves as a signal transducer, it is a player in cell adhesion and its …
anticancer drugs as it serves as a signal transducer, it is a player in cell adhesion and its …
Na+/K+ ATPase inhibitors in cancer
K Alevizopoulos, T Calogeropoulou, F Lang… - Current drug …, 2014 - ingentaconnect.com
Sodium potassium pump (Na+/K+ ATPase) is a transmembrane protein complex found in all
higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic …
higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic …
Transcriptional regulators of Na, K-ATPase subunits
Z Li, SA Langhans - Frontiers in cell and developmental biology, 2015 - frontiersin.org
The Na, K-ATPase classically serves as an ion pump creating an electrochemical gradient
across the plasma membrane that is essential for transepithelial transport, nutrient uptake …
across the plasma membrane that is essential for transepithelial transport, nutrient uptake …
[HTML][HTML] Na/K-ATPase: Their role in cell adhesion and migration in cancer
CI da Silva, CF Gonçalves-de-Albuquerque… - Biochimie, 2021 - Elsevier
Abstract Na/K-ATPase (NKA) is a p-type transmembrane enzyme formed by three different
subunits (α, β, and γ gamma). Primarily responsible for transporting sodium and potassium …
subunits (α, β, and γ gamma). Primarily responsible for transporting sodium and potassium …
The α1 subunit of the sodium pump could represent a novel target to combat non‐small cell lung cancers
T Mijatovic, I Roland, E Van Quaquebeke… - The Journal of …, 2007 - Wiley Online Library
With an overall 5 year survival rate as low as 15% for non‐small cell lung cancer (NSCLC),
even with surgical intervention and the use of newer molecules in adjuvant chemotherapy …
even with surgical intervention and the use of newer molecules in adjuvant chemotherapy …