Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship …

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in
subjects with cognitive impairment. However, the relationship between CVD, amyloid …

Background and Purpose—Brain atrophy, cortical infarction, and subcortical ischemic
vasculopathy have all been associated with cognitive dysfunction. The interrelationships …

Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and
increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) …

Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …

Background Markers of cerebrovascular disease are common in dementia, and may be
present before dementia onset. However, their clinical relevance in midlife adults at risk of …

Background Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their
influence on neurodegeneration and cognition in predementia stages remains unclear. We …

Abstract Background/Aim: To investigate the impact of vascular burden (assessed by the
number of vascular risk factors and diseases) on the cognition of persons with amnestic mild …

Objective: To determine the independent and synergistic effects of amyloid and small vessel
disease (SVD) burden on longitudinal cognitive decline in patients with subcortical vascular …

Importance It is not clear how common pure vascular cognitive impairment (VCI) is in the
absence of Alzheimer disease (AD) and/or other neurodegenerative pathologies. Objective …