Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …

Translation feedback control in the brain | Nature Reviews Molecular Cell Biology Skip to main
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Among the three phases of mRNA translation—initiation, elongation, and termination—
initiation has traditionally been considered to be rate limiting and thus the focus of …

Ribosome-associated quality control pathways respond to defects in translational elongation
to recycle arrested ribosomes and degrade aberrant polypeptides and mRNAs. Loss of a …

Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

Glioma growth is driven by signaling that ultimately regulates protein synthesis. Gliomas are
also complex at the cellular level and involve multiple cell types, including transformed and …

Translation regulation occurs largely during the initiation phase. Here, we develop selective
40S footprinting to visualize initiating 40S ribosomes on endogenous mRNAs in vivo. This …

Ribosomes are among the most abundant and complex machineries in the cell, however,
the turnover of their subunits remains poorly understood. Here, we apply proteomic flux and …

The broad impact of translational regulation has emerged explosively in the last few years in
part due to the technological advance in genome-wide interrogation of gene expression …