Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-
induced hepatotoxicity remains a significant public health concern and common indication …

Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …

Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …

Drug-induced liver injury is an important clinical problem and a challenge for drug
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …

Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at
therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The …

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen
overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most …

Acetaminophen (APAP) is a widely used analgesic that can be found alone and in
combination with other medications in more than 100 over-thecounter preparations and …

Acetaminophen has been widely used for> 50 years in the treatment of pain and fever and
provides for the safe and effective relief of these symptoms. In a small minority of patients …

The acetaminophen nomogram including its uses and limitations is discussed as well as the
development of the N-acetylcysteine protocol. While it has taken many years to elucidate the …