Drug resistance is one of the biggest challenges in cancer treatment and limits the potential
to cure patients. In many tumors, sustained activation of the protein NRF2 makes tumor cells …

Drug resistance during chemotherapy is the major obstacle to the successful treatment of
many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a …

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and
antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low …

Abstract NF-E2-related factor 2 (NRF2) is a master regulator of redox homeostasis and
provides cellular protection against oxidants and electrophiles by inducing the expression of …

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) plays a crucial role in the
upregulation of a wide array of genes that are associated with the maintenance of …

Nrf2 is a key transcription factor, which induces a cytoprotective gene array. Nrf2 is regulated
at the posttranslational level through proteasomal degradation through an interaction with …

Activating mutations in the KEAP1-NRF2 pathway are found in approximately 25% of lung
tumors, where the hijacking of NRF2's cytoprotective functions results in aggressive tumor …

The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and
electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Cancer cells first adapt to the microenvironment and then propagate. Mutations in tumor
suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive …