Heat‐killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome

HX Fan, S Sheng, DD Li, JJ Li… - Bioengineering & …, 2023 - Wiley Online Library
The intestinal flora has become very active in studies related to Parkinson's disease (PD) in
recent years. The microbe‐gut‐brain axis is closely related to the maintenance of brain …

Neuroprotective Effects of Lactobacillus plantarum PS128 in a Mouse Model of Parkinson's Disease: The Role of Gut Microbiota and MicroRNAs

YZ Lee, SH Cheng, MY Chang, YF Lin, CC Wu… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by motor deficits
and marked neuroinflammation in various brain regions. The pathophysiology of PD is …

Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson's Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids …

C Chu, L Yu, Y Li, H Guo, Q Zhai, W Chen, F Tian - Nutrients, 2023 - mdpi.com
Recent studies have demonstrated that disturbances in the gut microbiota and microbiota-
derived metabolites contribute to the pathogenesis of Parkinson's disease (PD), suggesting …

Perillyl alcohol attenuates NLRP3 inflammasome activation and rescues dopaminergic neurons in experimental in vitro and in vivo models of Parkinson's Disease

S Ahmed, SR Panda, M Kwatra, BD Sahu… - ACS chemical …, 2021 - ACS Publications
NLRP3 activation plays a key role in the initiation and progression of a variety of
neurodegenerative diseases. However, understanding the molecular mechanisms involved …

Ellagic acid protects dopamine neurons via inhibition of NLRP3 inflammasome activation in microglia

X He, Y Zhou, S Sheng, J Li, G Wang… - … Medicine and Cellular …, 2020 - Wiley Online Library
Neuroinflammation plays a crucial role in the pathological process of Parkinson's disease
(PD). Nod‐like receptor protein 3 (NLRP3) inflammasome was highly located in microglia …

[HTML][HTML] Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse models of …

JF Liao, YF Cheng, ST You, WC Kuo, CW Huang… - Brain, behavior, and …, 2020 - Elsevier
Evidence suggests that the Parkinson's disease (PD) pathogenesis is strongly associated
with bidirectional pathways in the microbiota-gut-brain axis (MGBA), and psychobiotics may …

Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons

T Zhang, T Wang, X Chen… - Experimental and …, 2022 - spandidos-publications.com
The composition of the intestinal flora of patients with Parkinson's disease (PD) can change.
However, whether reshaping the gut microbial composition can treat PD remains to be seen …

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease

C Qiao, Q Zhang, Q Jiang, T Zhang, M Chen… - Journal of …, 2018 - Springer
Background Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss
of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate …

A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson's disease

B Aktas, B Aslim, DA Ozdemir - Scientific Reports, 2024 - nature.com
The gut microbiota plays a crucial role in neural development and progression of neural
disorders like Parkinson's disease (PD). Probiotics have been suggested to impact …

Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson's Disease: Implications for Gut Microbiota and PGC-1α

Y Dong, Y Qi, J Chen, S Han, W Su, X Ma, Y Yu… - Molecular …, 2024 - Springer
Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and
probiotics have emerged as potential modulators of central nervous system function through …