Chronic neuropathic pain (CNP) is caused by a lesion or disease of the somatosensory
nervous system. It affects~ 8% of the general population and negatively impacts a person's …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

It is widely accepted that communication between the nervous and immune systems is
involved in the development of chronic pain. At each level of the nervous system, immune …

Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a
tremendous impact on the physiological functions of the body, manifesting itself as a …

The immune system is critically involved in the development and maintenance of chronic
pain. However, T cells, one of the main regulators of the immune response, have only …

It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Ongoing research has strongly suggested the role the immune system plays in the
pathogenesis of neuropathic pain. T cells appear to be one of the main regulators of the …