Chronic pain after spinal cord injury: is there a role for neuron-immune dysregulation?
SS Chambel, I Tavares, CD Cruz - Frontiers in Physiology, 2020 - frontiersin.org
Spinal cord injury (SCI) is a devastating event with a tremendous impact in the life of the
affected individual and family. Traumatic injuries related to motor vehicle accidents, falls …
affected individual and family. Traumatic injuries related to motor vehicle accidents, falls …
Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense
ET Walters - Experimental neurology, 2014 - Elsevier
Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be
severely debilitating. A number of mechanisms have been proposed for this pain, which are …
severely debilitating. A number of mechanisms have been proposed for this pain, which are …
Gliopathy ensures persistent inflammation and chronic pain after spinal cord injury
CE Hulsebosch - Experimental neurology, 2008 - Elsevier
Research focused on improving recovery of function, including the reduction of central
neuropathic pain (CNP) after spinal cord injury (SCI) is essential. After SCI, regional …
neuropathic pain (CNP) after spinal cord injury (SCI) is essential. After SCI, regional …
Neuronal‐glial interactions maintain chronic neuropathic pain after spinal cord injury
YS Gwak, CE Hulsebosch, JW Leem - Neural plasticity, 2017 - Wiley Online Library
The hyperactive state of sensory neurons in the spinal cord enhances pain transmission.
Spinal glial cells have also been implicated in enhanced excitability of spinal dorsal horn …
Spinal glial cells have also been implicated in enhanced excitability of spinal dorsal horn …
[HTML][HTML] Neuropathic pain: role of inflammation, immune response, and ion channel activity in central injury mechanisms
D Schomberg, M Ahmed, G Miranpuri… - Annals of …, 2012 - ncbi.nlm.nih.gov
Neuropathic pain (NP) is a significant and disabling clinical problem with very few
therapeutic treatment options available. A major priority is to identify the molecular …
therapeutic treatment options available. A major priority is to identify the molecular …
Cell and molecular approaches to the attenuation of pain after spinal cord injury
MJ Eaton - Journal of neurotrauma, 2006 - liebertpub.com
Recent experimental research to treat spinal cord injury (SCI) pain has greatly increased our
understanding of how such chronic pain might be modulated in the human population …
understanding of how such chronic pain might be modulated in the human population …
Spinal cord injury: a model of central neuropathic pain
RP Yezierski - Neurosignals, 2005 - karger.com
The condition of pain after spinal cord injury (SCI) affects the life quality of nearly 70% of
individuals with SCI. Clinical studies over the past decade have provided important insights …
individuals with SCI. Clinical studies over the past decade have provided important insights …
How is chronic pain related to sympathetic dysfunction and autonomic dysreflexia following spinal cord injury?
ET Walters - Autonomic Neuroscience, 2018 - Elsevier
Autonomic dysreflexia (AD) and neuropathic pain occur after severe injury to higher levels of
the spinal cord. Mechanisms underlying these problems have rarely been integrated in …
the spinal cord. Mechanisms underlying these problems have rarely been integrated in …
Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications
Y Jin, Y Song, J Lin, T Liu, G Li, B Lai, Y Gu… - Burns & …, 2023 - academic.oup.com
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete
loss of motor and sensory function. Massive neurons are damaged after the initial …
loss of motor and sensory function. Massive neurons are damaged after the initial …
Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences
J Wieseler-Frank, SF Maier, LR Watkins - Brain, behavior, and immunity, 2005 - Elsevier
This review examines recently recognized roles of immunological processes in pain
modulation and explores the potential implications of these immunologically derived …
modulation and explores the potential implications of these immunologically derived …
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