Chronic exposure of laboratory animals to cigarette smoke reproduces many of the
anatomic/physiologic lesions (emphysema, small-airway remodeling and pulmonary …

Recent years have seen an explosion of animal models of cigarette smoke-induced chronic
obstructive lung disease (COPD). Almost all of these have concentrated on the induction …

Animal models of cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
provide potentially useful ways to test drug therapies, either by direct administration of the …

There is a very large number of experimental approaches that prevent cigarette smoke–
induced emphysema in laboratory animals, but the few similar treatments that have been …

Objectives To review the animal models of COPD, and to compare these data to those found
in humans. Results Smoke-induced animal models can produce emphysema, although the …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Mouse models of chronic obstructive pulmonary disease (COPD) focus on airway
inflammation and lung histology, but their use has been hampered by the lack of pulmonary …

Small animal models of chronic obstructive pulmonary disease (COPD) have several
limitations for identifying new therapeutic targets and biomarkers for human COPD. These …