Precision medicine in oncology is the result of an increasing awareness of patient‐specific
clinical features coupled with the development of genomic‐based diagnostics and targeted …

The concept of oncogene addiction was first proposed by Weinstein in 2002, postulating that
tumors rely on a single dominant mutation, the oncogenic “driver”, for growth and survival …

Abstract “Precision” trials, using rationally incorporated biomarker targets and molecularly
selective anticancer agents, have become of great interest to both patients and their …

In recent years, biotechnological breakthroughs have led to identification of complex and
unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling …

Simple Summary Precision oncology is the use of anticancer drugs to specifically inhibit the
function of aberrant oncogenic proteins driving a patient's tumor. The application of …

Matched therapy based on next-generation sequencing is now a part of routine care to
guide the treatment of patients with advanced solid tumors. However, whether and to what …

Precision oncology is not an illusion, nor is it the magic bullet that will eradicate all cancers.
Precision oncology is simply another weapon in our growing armament against cancer …

With the advent of high-throughput molecular technologies, several precision medicine (PM)
studies are currently ongoing that include molecular screening programs and PM clinical …

Precision medicine continues to be the benchmark to which we strive in cancer research.
Seeking out actionable aberrations that can be selectively targeted by drug compounds …

The utilization of genomic data to direct treatment for cancer patients represents the central
tenet in precision oncology, in which a patient is matched to a specific drug or therapy based …