Extending the application of biocatalysis to meet the challenges of drug development
PN Devine, RM Howard, R Kumar… - Nature Reviews …, 2018 - nature.com
The pharmaceutical industry, driven by an increasing need to deliver new and more effective
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …
Biocatalysis in the pharmaceutical industry: the need for speed
MD Truppo - ACS Medicinal Chemistry Letters, 2017 - ACS Publications
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of
increased access to enzymes and the ability to engineer those enzymes to meet the …
increased access to enzymes and the ability to engineer those enzymes to meet the …
Biocatalysis in drug discovery and development
A Fryszkowska, PN Devine - Current Opinion in Chemical Biology, 2020 - Elsevier
Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …
beginning to transform chemical synthesis in the pharmaceutical industry. This review …
[图书][B] Biocatalysis for the pharmaceutical industry: discovery, development, and manufacturing
JA Tao, GQ Lin, A Liese - 2009 - books.google.com
Biocatalysis is rapidly evolving into a key technology for the discovery and production of
chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio …
chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio …
Emerging technologies for biocatalysis in the pharmaceutical industry
Biocatalysis is a key technology in the pharmaceutical industry as it can provide efficient and
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …
Embracing nature's catalysts: a viewpoint on the future of biocatalysis
B Hauer - Acs Catalysis, 2020 - ACS Publications
Enzymes are nature's catalysts that are designed to accelerate specific reactions up to 106
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …
On the development of new biocatalytic processes for practical pharmaceutical synthesis
GW Huisman, SJ Collier - Current opinion in chemical biology, 2013 - Elsevier
Biocatalysis has established itself as a scalable and green technology for the production of a
broad range of pharmaceutical APIs and intermediates. The number and scope of …
broad range of pharmaceutical APIs and intermediates. The number and scope of …
Biocatalysis: A pharma perspective
JP Adams, MJB Brown… - Advanced Synthesis …, 2019 - Wiley Online Library
Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …
Biocatalysis explained: from pharmaceutical to bulk chemical production
EMM Abdelraheem, H Busch, U Hanefeld… - Reaction Chemistry & …, 2019 - pubs.rsc.org
Biocatalysis is one of the most promising technologies for the sustainable synthesis of
molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to …
molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to …
Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis
CM Clouthier, JN Pelletier - Chemical Society Reviews, 2012 - pubs.rsc.org
This critical review presents an introduction to biocatalysis for synthetic chemists. Advances
in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and …
in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and …