Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

During cancer progression, tumor cells undergo molecular and phenotypic changes
collectively referred to as cellular plasticity. Such changes result from microenvironmental …

Most tumors exhibit intra-tumor heterogeneity, which is associated with disease progression
and an impaired response to therapy. Cancer cell plasticity has been proposed as being an …

Historically, it has been widely presumed that differentiated cells are determined during
development and become irreversibly committed to their designated fates. In certain …

Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Cancer cells are plastic–they can assume a wide range of distinct phenotypes. Plasticity is
integral to cancer initiation and progression, as well as to the emergence and maintenance …

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Most solid cancer-related deaths result from metastasis, a multistep process in which cancer
cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …