During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor receptor family. It
was first identified and functionally characterized on B lymphocytes; however, in recent …

It is clear by now that cell-to-cell interactions involving a variety of signals are required for
effective immune response. The data reviewed here suggest that CD40-CD40L interactions …

For several years, the primary function of CD40 ligand (CD40L) has been believed to be in
regulation of contact-dependent, CD40-CD40L-mediated signals between B-and T-cells …

A successful immune response requires the coordinated interaction of multiple cell types.
The interactioti between T-helper cells (Th) and antigen-presenting cells (APC) such as B …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

Abstract CD40 and CD40 ligand (CD40L) have been implicated as important molecules for
the transformation of nonactivated antigen-presenting cells (APC) into cells that are potent …

ABSTRACT TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …

The first signal is antigen specific; it is delivered via the antigen-specific T-cell surface
receptor (TCR) when antigen is properly presented to the T cell in the context of major …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …