Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell
Z Yang, X Yang, Y Li, Y Cai, Y Yu, W Zhuang… - European Journal of …, 2023 - Elsevier
The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR …
YS Li, X Yang, DS Zhao, Y Cai, Z Huang, R Wu… - European Journal of …, 2021 - Elsevier
Abstract P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a phenomenon in
which cells become resistant to structurally and mechanistically unrelated drugs resulting in …
which cells become resistant to structurally and mechanistically unrelated drugs resulting in …
Discovery of 2, 5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell
Z Yang, Y Cai, S Mao, Q Wu, M Zhu, X Cao… - European Journal of …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp) is one of the drug efflux transporters that triggers multidrug
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
Structure− activity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors
CY Chen, CM Lin, HC Lin, CF Huang, CY Lee… - European Journal of …, 2017 - Elsevier
Abstract Treatment of cancer patients with chemotherapeutic drugs is often associated with
the occurrence of tumors with a multidrug resistance (MDR). Furthermore, the relation …
the occurrence of tumors with a multidrug resistance (MDR). Furthermore, the relation …
Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell
YS Li, S Mao, DS Zhao, CC Wang, D Zu, X Yang… - Bioorganic …, 2021 - Elsevier
Abstract P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) has become an
important hindrance in the clinical treatment of malignant tumors. In this paper, based on our …
important hindrance in the clinical treatment of malignant tumors. In this paper, based on our …
Synthesis and biological evaluation of 2, 5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell
YS Li, DS Zhao, XY Liu, YX Liao, HW Jin… - European journal of …, 2018 - Elsevier
Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and
mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the …
mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the …
Novel benzo five-membered heterocycle derivatives as P-glycoprotein inhibitors: design, synthesis, molecular docking, and anti-multidrug resistance activity
Z Yang, Y Cai, X Yang, Y Li, Q Wu, Y Yu… - Journal of Medicinal …, 2023 - ACS Publications
A proposed strategy to overcome multidrug resistance (MDR) of anticancer drugs in
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …
Design, synthesis and biological evaluation of N-(4-(2-(6, 7-dimethoxy-3, 4-dihydroisoquinolin-2 (1H)-yl) ethyl) phenyl)-4-oxo-3, 4-dihydrophthalazine-1-carboxamide …
Q Qiu, J Zhou, W Shi, M Kairuki, W Huang, H Qian - Bioorganic Chemistry, 2019 - Elsevier
The overexpression of P-glycoprotein plays an important role in the process of multidrug
resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR …
resistance (MDR). P-gp inhibitors are one of the effective strategies to reverse tumor MDR …
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors
Y Gao, W Shi, J Cui, C Liu, X Bi, Z Li, W Huang… - Bioorganic & Medicinal …, 2018 - Elsevier
Multidrug resistance (MDR) is one of the main obstacles of clinical chemotherapy. A great
deal of research shows that the occurrence of drug resistance in various malignant tumors is …
deal of research shows that the occurrence of drug resistance in various malignant tumors is …
Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell
Z Yang, D Luo, C Shao, H Hu, X Yang, Y Cai… - European Journal of …, 2024 - Elsevier
The inhibition of P-glycoprotein (P-gp) has emerged as an intriguing strategy for
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
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