The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling
pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide …

Since its discovery in the early 1990s, the Janus kinase (JAK)-signal transducer and
activator of transcription (STAT) signaling pathway has been found to play key roles in …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated by many cytokines and growth factors and plays a key role in cell survival …

Growth hormone controls many facets of a cell's biology through the transcription factors
Stat5a and Stat5b (Stat5). However, whole body deletion of these genes from the mouse …

Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family
and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to …

Sepsis is an infection‐induced syndrome with systemic inflammatory response leading to
multiorgan failure and occasionally death. During this process, signal transducer and …

T cell–mediated fulminant hepatitis is a life-threatening event for which the underlying
mechanism is not fully understood. Injection of concanavalin A (Con A) into mice …

Introduction 2.1. Liver fibrosis and cirrhosis in humans 2.2. Chronic injury–fibrosis–cirrhosis-
HCC axis 2.3. Cellular basis and molecular pathways in liver fibrosis 2.4. Genetic and …

Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor,
primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides …