Comparison of Inhaled Drug Delivery in Patients With One‐and Two‐level Laryngotracheal Stenosis
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a functionally devastating condition
with high respiratory morbidity and mortality. This preliminary study investigates airflow …
with high respiratory morbidity and mortality. This preliminary study investigates airflow …
A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway
Laryngotracheal stenosis (LTS) is a type of airway narrowing that is frequently caused by
intubation-related trauma. LTS can occur at one or multiple locations in the larynx and/or …
intubation-related trauma. LTS can occur at one or multiple locations in the larynx and/or …
Orally inhaled drug particle transport in computerized models of laryngotracheal stenosis
DO Frank-Ito, SM Cohen - Otolaryngology–Head and Neck …, 2021 - journals.sagepub.com
Objective Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …
Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics
T Cheng, D Carpenter, S Cohen, D Witsell… - The …, 2018 - Wiley Online Library
Objective Very little is known about the impact of laryngotracheal stenosis (LTS) on
inspiratory airflow and resistance, especially in air hunger states. This study investigates the …
inspiratory airflow and resistance, especially in air hunger states. This study investigates the …
Model for Pharmaceutical aerosol transport through stenosis airway
Air pollution is one of the critical factors that has threatened human health for a long time. In
the early 20th century, people worldwide were aware of the health effects that were caused …
the early 20th century, people worldwide were aware of the health effects that were caused …
[HTML][HTML] Effects of vocal fold adduction on the particle deposition in the glottis: A numerical analysis and in vitro assessment
P Yu, C Xue, B Boeckenstedt, H Olsen… - Computers in Biology and …, 2023 - Elsevier
Background The efficacy of inhalation therapy depends on the drug deposition in the human
respiratory tract. This study investigates the effects of vocal fold adduction on the particle …
respiratory tract. This study investigates the effects of vocal fold adduction on the particle …
Glottal motion and its impact on airflow and aerosol deposition in upper airways during human breathing
A Scheinherr - 2015 - theses.hal.science
During inhaled therapies several factors limits the amount of drug delivered to the lungs. Eg
the upper airways morphology and in particular the glottis, defined by the vocal-fold …
the upper airways morphology and in particular the glottis, defined by the vocal-fold …
Tracheal stenosis: a CFD approach for evaluation of drug delivery
S Taherian, H Rahai, BZ Gomez… - ASME …, 2015 - asmedigitalcollection.asme.org
The existence of obstructions such as tracheal stenosis has major impacts on respiratory
functions. Therapeutic effectiveness of inhaled medications is influenced by tracheal …
functions. Therapeutic effectiveness of inhaled medications is influenced by tracheal …
[HTML][HTML] Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model
Despite the prevalence of inhalation therapy in the treatment of various respiratory diseases,
predicting and optimizing lung deposition fractions of inhaled drugs for maximal efficacy …
predicting and optimizing lung deposition fractions of inhaled drugs for maximal efficacy …
[HTML][HTML] Understanding the effects of inhaler resistance on particle deposition behaviour–A computational modelling study
Background and objective Understanding the impact of inhaler resistance on particle
transport and deposition in the human upper airway is essential for optimizing inhaler …
transport and deposition in the human upper airway is essential for optimizing inhaler …