Comparison of Inhaled Drug Delivery in Patients With One‐and Two‐level Laryngotracheal Stenosis

RE Gosman, RM Sicard, SM Cohen… - The …, 2023 - Wiley Online Library
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a functionally devastating condition
with high respiratory morbidity and mortality. This preliminary study investigates airflow …

A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway

RE Gosman, RM Sicard, SM Cohen… - Experimental and …, 2023 - Springer
Laryngotracheal stenosis (LTS) is a type of airway narrowing that is frequently caused by
intubation-related trauma. LTS can occur at one or multiple locations in the larynx and/or …

Orally inhaled drug particle transport in computerized models of laryngotracheal stenosis

DO Frank-Ito, SM Cohen - Otolaryngology–Head and Neck …, 2021 - journals.sagepub.com
Objective Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …

Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics

T Cheng, D Carpenter, S Cohen, D Witsell… - The …, 2018 - Wiley Online Library
Objective Very little is known about the impact of laryngotracheal stenosis (LTS) on
inspiratory airflow and resistance, especially in air hunger states. This study investigates the …

Model for Pharmaceutical aerosol transport through stenosis airway

P Larpruenrudee, MS Islam, G Paul… - Handbook of Lung …, 2021 - api.taylorfrancis.com
Air pollution is one of the critical factors that has threatened human health for a long time. In
the early 20th century, people worldwide were aware of the health effects that were caused …

[HTML][HTML] Effects of vocal fold adduction on the particle deposition in the glottis: A numerical analysis and in vitro assessment

P Yu, C Xue, B Boeckenstedt, H Olsen… - Computers in Biology and …, 2023 - Elsevier
Background The efficacy of inhalation therapy depends on the drug deposition in the human
respiratory tract. This study investigates the effects of vocal fold adduction on the particle …

Glottal motion and its impact on airflow and aerosol deposition in upper airways during human breathing

A Scheinherr - 2015 - theses.hal.science
During inhaled therapies several factors limits the amount of drug delivered to the lungs. Eg
the upper airways morphology and in particular the glottis, defined by the vocal-fold …

Tracheal stenosis: a CFD approach for evaluation of drug delivery

S Taherian, H Rahai, BZ Gomez… - ASME …, 2015 - asmedigitalcollection.asme.org
The existence of obstructions such as tracheal stenosis has major impacts on respiratory
functions. Therapeutic effectiveness of inhaled medications is influenced by tracheal …

[HTML][HTML] Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model

S Bhardwaj, P Koullapis, SC Kassinos… - European Journal of …, 2022 - Elsevier
Despite the prevalence of inhalation therapy in the treatment of various respiratory diseases,
predicting and optimizing lung deposition fractions of inhaled drugs for maximal efficacy …

[HTML][HTML] Understanding the effects of inhaler resistance on particle deposition behaviour–A computational modelling study

X Cai, J Dong, L Milton-McGurk, A Lee, Z Shen… - Computers in Biology …, 2023 - Elsevier
Background and objective Understanding the impact of inhaler resistance on particle
transport and deposition in the human upper airway is essential for optimizing inhaler …