α2-agonists have been extensively used and studied in anaesthesia and intensive care
medicine. A list of benefits includes anxiolysis, blood pressure stabilization, analgesia …

Two α2-agonists are currently available for peri-operative use—clonidine and
dexmedetomidine. These α2-agonists have sympatholytic, analgesic, sedative and …

Clonidine and other clinically available alpha-2 adrenergic agonists reduce inhalational and
narcotic anesthetic requirements while providing hemodynamic stability during stressful …

α 2-Agonists are a novel class of drugs with mechanisms of action that differ from other
commonly used anesthetic drugs. They have neuroprotective, cardioprotective, and sedative …

Resurgence in interest in a2-adrenergic agonists has been fuelled by the emergence of
dexmedetomidine, the latest a2-agonist to be developed. Recently licensed in the USA, it …

Dexmedetomidine, a highly selective, specific and potent alpha2 agonist, is the dextro-
stereoisomer and pharmacologically active component of medetomidine, which has been …

Background: Clonidine, an α 2 agonist, has been used in anesthesia for many years to
provide sedation, anxiolysis, analgesia, controlled hypotension, and to provide opioid …

Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well
as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity …

Both alpha 2-adrenergic agonists and benzodiazepines exert anxiolytic and sedative effects
when administered as preoperative medications. Clinical effects achieved with a …

Correspondence: Dr. TVSP Murthy, E-mail: tvspmurthy@ yahoo. com pressure; and
decreased insulin release from the pancreas. 1 In general, presynaptic activation of the …