Defensins: defenders of human reproductive health

YJ Zhai, Y Feng, X Ma, F Ma - Human reproduction update, 2023 - academic.oup.com
BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans

E Com, F Bourgeon, B Evrard, T Ganz… - Biology of …, 2003 - academic.oup.com
Defensins are antimicrobial peptides that play a major role in innate immunity. Using reverse
transcriptase-polymerase chain reaction, immunochemistry, or both, we performed a search …

[HTML][HTML] Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)

S Yenugu, V Chintalgattu, CJ Wingard… - Reproductive Biology …, 2006 - Springer
Background beta-defensins are small cationic peptides that exhibit broad spectrum
antimicrobial properties. The majority of beta-defensins identified in humans are …

Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium

AE King, DC Fleming, HOD Critchley… - Journal of reproductive …, 2003 - Elsevier
β-Defensins are small cationic molecules that have antimicrobial actions against bacteria,
fungi and viruses and contribute to mucosal immune responses at epithelial sites. The …

Defensins:“Simple” antimicrobial peptides or broad-spectrum molecules?

M Suarez-Carmona, P Hubert, P Delvenne… - Cytokine & growth factor …, 2015 - Elsevier
Small cationic peptides highly conserved in vertebrates, both α-and β-defensins were
primarily identified as anti-microbial compounds involved in innate immunity. While human α …

β-Defensins: multifunctional modulators of infection, inflammation and more?

F Semple, JR Dorin - Journal of innate immunity, 2012 - karger.com
Defensins comprise one of the largest groups of host defence peptides, present throughout
evolution, in fungi and flowering plants as well as in invertebrates and vertebrates. These …

[HTML][HTML] β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios

CM Ribeiro, EJR Silva, BT Hinton… - Asian journal of …, 2016 - journals.lww.com
Abstract β-defensins are components of host defense, with antimicrobial and pleiotropic
immuno-modulatory properties. Research over the last 15 years has demonstrated …

A novel subclass of bovine β-defensins links reproduction and immunology

F Narciandi, A Lloyd, KG Meade… - Reproduction, Fertility …, 2014 - CSIRO Publishing
β-defensins are effector molecules of the innate immune system, found in many diverse
species. Their presence in invertebrates as well as vertebrates suggests highly conserved …

Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract

F Narciandi, B Fernandez-Fuertes… - Biology of …, 2016 - academic.oup.com
Beta-defensins are innate immune molecules, often described as antimicrobial peptides
because of their bactericidal activity and are now known to have diverse additional …

[HTML][HTML] Identification on mouse chromosome 8 of new β-defensin genes with regionally specific expression in the male reproductive organ

A Zaballos, R Villares, JP Albar, C Martínez-A… - Journal of Biological …, 2004 - ASBMB
Defensins are important elements in innate immunity that can also trigger adaptive immune
responses. The defensins form a family of small cationic antimicrobial peptides with six …