Protein structure is key to understanding biological function. Structure comparison deciphers
deep phylogenies, providing insight into functional conservation and functional shifts during …

Objectives Structure determination will benefit from genomics in two ways (Figure 1). Firstly,
the mass of available sequences will facilitate the quick determination of structure for most …

Abstract The Structural Classification of Proteins—extended (SCOPe, https://scop. berkeley.
edu) knowledgebase aims to provide an accurate, detailed, and comprehensive description …

Many protein classification systems capture homologous relationships by grouping domains
into families and superfamilies on the basis of sequence similarity. Superfamilies with similar …

We are now entering a new era in protein sequence and structure annotation, with hundreds
of millions of predicted protein structures made available through the AlphaFold database …

Abstract SCOPe (Structural Classification of Proteins—extended, http://scop. berkeley. edu)
is a database of relationships between protein structures that extends the Structural …

Abstract SMART (Simple Modular Architecture Research Tool) is a web resource
(http://smart. embl. de/) providing simple identification and extensive annotation of protein …

For the past half-century, structural biologists relied on the notion that similar protein
sequences give rise to similar structures and functions. While this assumption has driven …

Proteins are key to all cellular processes and their structure is important in understanding
their function and evolution. Sequence-based predictions of protein structures have …

Highly accurate structure prediction methods are generating an avalanche of publicly
available protein structures. Searching through these structures is becoming the main …