Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

[HTML][HTML] Current knowledge and novel frontiers in lower urinary tract dysfunction after spinal cord injury: Basic research perspectives

N Wada, S Karnup, K Kadekawa, N Shimizu… - Urological …, 2022 - journals.lww.com
This review article aims to summarize the recent advancement in basic research on lower
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …

Characterization of lower urinary tract dysfunction after thoracic spinal cord injury in Yucatan Minipigs

MS Keung, F Streijger, A Herrity, J Ethridge… - Journal of …, 2021 - liebertpub.com
There is an increasing need to develop approaches that will not only improve the clinical
management of neurogenic lower urinary tract dysfunction (NLUTD) after spinal cord injury …

Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model

T Saito, D Gotoh, N Wada, P Tyagi… - American Journal …, 2021 - journals.physiology.org
This study evaluated the time-course changes in bladder and external urinary sphincter
(EUS) activity and the expression of mechanosensitive channels in lumbosacral dorsal root …

Functional deficits and morphological changes in the neurogenic bladder match the severity of spinal cord compression

O Ozsoy, U Ozsoy, G Stein, O Semler… - Restorative …, 2012 - content.iospress.com
Following spinal cord injury (SCI), loss of spinal and supraspinal control results in
desynchronisation of detrusor vesicae (parasympathicus) and external urethral sphincter …

Molecular characterization of non-neurogenic and neurogenic lower urinary tract dysfunction (LUTD) in SCI-induced and partial bladder outlet obstruction mouse …

M von Siebenthal, A Akshay, M Besic… - International journal of …, 2023 - mdpi.com
We examined bladder function following spinal cord injury (SCI) by repeated urodynamic
investigation (UDI), including external urethral sphincter (EUS) electromyography (EMG) in …

Pharmacologic and potential biologic interventions to restore bladder function after spinal cord injury

N Yoshimura, CP Smith, MB Chancellor… - Current opinion in …, 2000 - journals.lww.com
Spinal cord injury disrupts voluntary control of voiding and the normal reflex pathways that
coordinate bladder and urethral sphincter function. The present review addresses studies in …

Neurogenic bladder physiology, pathogenesis, and management after spinal cord injury

NE Perez, NP Godbole, K Amin, R Syan… - Journal of personalized …, 2022 - mdpi.com
Urinary incontinence is common after spinal cord injury (SCI) due to loss of supraspinal
coordination and unabated reflexes in both autonomic and somatic nervous systems; if …

Molecular mechanisms of neurogenic lower urinary tract dysfunction after spinal cord injury

N Shimizu, T Saito, N Wada, M Hashimoto… - International journal of …, 2023 - mdpi.com
This article provides a synopsis of current progress made in fundamental studies of lower
urinary tract dysfunction (LUTD) after spinal cord injury (SCI) above the sacral level. Animal …

Coordination of the bladder detrusor and the external urethral sphincter in a rat model of spinal cord injury: effect of injury severity

V Pikov, JR Wrathall - Journal of Neuroscience, 2001 - Soc Neuroscience
Recovery of urinary tract function after spinal cord injury (SCI) is important in its own right
and may also serve as a model for studying mechanisms of functional recovery after injury in …