Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a
focus on translational studies aimed at developing novel approaches to modulate PSC …

There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal
role in the development of pancreatic fibrosis within the pancreatic cancer tissue. Not only …

Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence
ratio. Traditional therapeutic approaches such as surgery in combination with chemo-or …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

The abundant stromal/desmoplastic reaction, a characteristic feature of a majority of
pancreatic adenocarcinomas (PDAC), has only recently been receiving some attention …