Decades of successful use of antibiotics is currently challenged by the emergence of
increasingly resistant bacterial strains. Novel drugs are urgently required but, in a scenario …

Over the past decade, the availability of complete microbial genome sequences has led to
changes in the strategies that are used to search for novel anti-infectives. However, despite …

The continued increase in antibiotic resistance among bacterial pathogens, coupled with a
decrease in infectious disease research among pharmaceutical companies, has escalated …

In this era of genomic science, knowledge about biological function is integrated
increasingly with DNA sequence data. One area that has been significantly impacted by this …

Over the past decade, the sequences of microbial genomes have accumulated, changing
the strategies for the discovery of novel anti-infective agents. Targets have become plentiful …

The process of prokaryotic drug discovery has been a model of success for over fifty years,
yet the number of exploited bacterial targets is a mere fraction, less than 0.1% of the …

▪ Abstract There is an urgent need to develop novel classes of antibiotics to counter the
threat of the spread of multiply resistant bacterial pathogens. The availability of the complete …

Over the past 40 years, the search for new antibiotics has been largely restricted to well-
known compound classes active against a standard set of drug targets. Although many …

Highlights•Bacterial core genomes consisting of essential genes could elucidate potential
targets.•Transcriptomics can identify genes involved in different aspects of host …

The global emergence of multi-drug resistant bacteria invokes an urgent and imperative
necessity for the identification of novel antimicrobials. The general lack of success in …