Emerging roles of the iron chelators in inflammation
A Di Paola, C Tortora, M Argenziano… - International Journal of …, 2022 - mdpi.com
Iron is a crucial element for mammalian cells, considering its intervention in several
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …
The utility of iron chelators in the management of inflammatory disorders
C Lehmann, S Islam, S Jarosch, J Zhou… - Mediators of …, 2015 - Wiley Online Library
Since iron can contribute to detrimental radical generating processes through the Fenton
and Haber‐Weiss reactions, it seems to be a reasonable approach to modulate iron‐related …
and Haber‐Weiss reactions, it seems to be a reasonable approach to modulate iron‐related …
The importance of iron in pathophysiologic conditions
R Gozzelino, P Arosio - Frontiers in pharmacology, 2015 - frontiersin.org
Biological iron is necessary for vital functions and also potentially toxic to the organisms.
This dual effect raised the interest of many investigators to study the mechanisms controlling …
This dual effect raised the interest of many investigators to study the mechanisms controlling …
Established and emerging concepts to treat imbalances of iron homeostasis in inflammatory diseases
V Petzer, I Theurl, G Weiss - Pharmaceuticals, 2018 - mdpi.com
Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory
bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron …
bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron …
Iron at the interface of immunity and infection
M Nairz, D Haschka, E Demetz, G Weiss - Frontiers in pharmacology, 2014 - frontiersin.org
Both, mammalian cells and microbes have an essential need for iron, which is required for
many metabolic processes and for microbial pathogenicity. In addition, cross-regulatory …
many metabolic processes and for microbial pathogenicity. In addition, cross-regulatory …
Importance of iron chelation in free radical-induced oxidative stress and human disease
Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of
cell growth and differentiation. Iron is an integral part of many proteins and enzymes that …
cell growth and differentiation. Iron is an integral part of many proteins and enzymes that …
Synthetic and natural iron chelators: therapeutic potential and clinical use
HC Hatcher, RN Singh, FM Torti… - Future medicinal …, 2009 - Taylor & Francis
Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …
years, the standard for this purpose has been deferoxamine. Recently, considerable …
Iron involvement in multiple signaling pathways of atherosclerosis: a revisited hypothesis
XM Yuan, W Li - Current medicinal chemistry, 2008 - ingentaconnect.com
Atherosclerosis being a leading death cause in many countries is a chronic inflammatory
process in which inflammation, immune activation, and oxidative stress are interactively …
process in which inflammation, immune activation, and oxidative stress are interactively …
Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries
R Paesano, T Natalizi, F Berlutti… - Pathogens and global …, 2012 - Taylor & Francis
Over 2 billion people in both developing as well as developed countries–over 30% of the
world's population–are anaemic. With the classical preconception that oral iron …
world's population–are anaemic. With the classical preconception that oral iron …
Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities
U Abbasi, S Abbina, A Gill, LE Takuechi… - ACS Chemical …, 2021 - ACS Publications
Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved
in vital cellular processes. The iron economy within humans is highly conserved in that there …
in vital cellular processes. The iron economy within humans is highly conserved in that there …