The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

CE Barry 3rd, HI Boshoff, V Dartois, T Dick… - Nature Reviews …, 2009 - nature.com
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Lazy, Dynamic or Minimally Recrudescent? On the Elusive Nature and Location of the Mycobacterium Responsible for Latent Tuberculosis

S Ehlers - Infection, 2009 - Springer
In the absence of symptoms characteristic of tuberculosis (TB), a condition termed clinical
latency, diagnosis is currently impossible by detection of the microorganism itself and resorts …

Eliminating latent tuberculosis

DB Young, HP Gideon, RJ Wilkinson - Trends in microbiology, 2009 - cell.com
Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of
infection is believed to exist in an asymptomatic 'latent'form that is defined not by the …

[HTML][HTML] Mechanisms of latency in Mycobacterium tuberculosis

NM Parrish, JD Dick, WR Bishai - Trends in microbiology, 1998 - cell.com
Mycobacterium tuberculosis can persist within the human host for years without causing
disease, in a syndrome known as latent tuberculosis (TB). As one-third of the world …

Diagnosis and management of latent tuberculosis infection

L Muñoz, HR Stagg, I Abubakar - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The post-2015 World Health Organization global tuberculosis strategy recognizes that
elimination requires a focus on reducing the pool of latently infected individuals, an …

Latent tuberculosis infection–revisiting and revising concepts

P Salgame, C Geadas, L Collins, E Jones-López… - Tuberculosis, 2015 - Elsevier
Host-and pathogen-specific factors interplay with the environment in a complex fashion to
determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one …

Understanding latent tuberculosis: a moving target

PL Lin, JAL Flynn - The Journal of Immunology, 2010 - journals.aai.org
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Latent tuberculosis infection: myths, models, and molecular mechanisms

NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

The ongoing challenge of latent tuberculosis

H Esmail, CE Barry 3rd, DB Young… - … Transactions of the …, 2014 - royalsocietypublishing.org
The global health community has set itself the task of eliminating tuberculosis (TB) as a
public health problem by 2050. Although progress has been made in global TB control, the …

Tuberculosis: latency and reactivation

JAL Flynn, J Chan - Infection and immunity, 2001 - Am Soc Microbiol
Tuberculosis is a major cause of death around the world, with most of the 1.5 million deaths
per year attributable to the disease occurring in developing countries. This disease is …