NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease

M Amani, M Zolghadrnasab, AA Salari - Physiology & behavior, 2019 - Elsevier
Many patients with sporadic Alzheimer's disease (AD) suffer from memory impairment,
anxiety-and depression. The systemic utility of N-Methyl-d-Aspartate (NMDA) receptor …

NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

MK Müller, E Jacobi, K Sakimura, R Malinow… - Acta Neuropathologica …, 2018 - Springer
Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early
events in Alzheimer's disease (AD) pathogenesis. N-methyl-D-aspartate receptors …

NMDA neurotransmission dysfunction in mild cognitive impairment and Alzheimer's disease

CH Lin, YJ Huang, CJ Lin, HY Lane… - Current pharmaceutical …, 2014 - ingentaconnect.com
The prevalence of Alzheimer's disease (AD) in the elderly is growing rapidly worldwide, and
the deteriorating clinical course of AD places a heavy burden on both the patients and their …

NMDA neurotransmission dysfunction in behavioral and psychological symptoms of Alzheimer's disease

YJ Huang, CH Lin, HY Lane… - Current …, 2012 - ingentaconnect.com
Dementia has become an all-important disease because the population is aging rapidly and
the cost of health care associated with dementia is ever increasing. In addition to cognitive …

NMDA receptor regulation of memory and behavior in humans

JW Newcomer, JH Krystal - Hippocampus, 2001 - Wiley Online Library
Abstract N‐methyl‐D‐aspartate (NMDA) receptor hypofunction is associated with a range of
effects on cognition and behavior in whole animal and human studies. NMDA receptor …

Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease

G Chen, P Chen, H Tan, D Ma, F Dou, J Feng… - Neurobiology of …, 2008 - Elsevier
The cholinergic system is crucial for cognitive processes and the deficient acetylcholine
(ACh) function has been implicated in Alzheimer's disease (AD). Inhibitors of …

Deficits in N-methyl-D-aspartate receptor function and synaptic plasticity in hippocampal CA1 in APP/PS1 mouse model of Alzheimer's disease

L Xu, Y Zhou, L Hu, H Jiang, Y Dong, H Shen… - Frontiers in Aging …, 2021 - frontiersin.org
The N-methyl-D-aspartate receptor is a critical molecule for synaptic plasticity and cognitive
function. Impaired synaptic plasticity is thought to contribute to the cognitive impairment …

Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals

A Kumar, A Rani, RB Scheinert, BK Ormerod… - Neurobiology of …, 2018 - Elsevier
A redox-mediated decrease in N-methyl-D-aspartate (NMDA) receptor function contributes
to psychiatric diseases and impaired cognition during aging. Inflammation provides a …

Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated …

J Ma, BR Choi, CH Chung, SS Min, WK Jeon, JS Han - Molecular brain, 2014 - Springer
Neuroinflammation plays a key role in the initiation and progression of neurodegeneration in
Alzheimer's disease (AD). Chronic neuroinflammation results in diminished synaptic …

Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors

S Rosi, V Ramirez-Amaya, B Hauss-Wegrzyniak… - Journal of …, 2004 - Springer
Background Neuroinflammation plays a prominent role in the progression of Alzheimer's
disease and may be responsible for degeneration in vulnerable regions such as the …