NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease
Many patients with sporadic Alzheimer's disease (AD) suffer from memory impairment,
anxiety-and depression. The systemic utility of N-Methyl-d-Aspartate (NMDA) receptor …
anxiety-and depression. The systemic utility of N-Methyl-d-Aspartate (NMDA) receptor …
NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice
MK Müller, E Jacobi, K Sakimura, R Malinow… - Acta Neuropathologica …, 2018 - Springer
Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early
events in Alzheimer's disease (AD) pathogenesis. N-methyl-D-aspartate receptors …
events in Alzheimer's disease (AD) pathogenesis. N-methyl-D-aspartate receptors …
NMDA neurotransmission dysfunction in mild cognitive impairment and Alzheimer's disease
The prevalence of Alzheimer's disease (AD) in the elderly is growing rapidly worldwide, and
the deteriorating clinical course of AD places a heavy burden on both the patients and their …
the deteriorating clinical course of AD places a heavy burden on both the patients and their …
NMDA neurotransmission dysfunction in behavioral and psychological symptoms of Alzheimer's disease
Dementia has become an all-important disease because the population is aging rapidly and
the cost of health care associated with dementia is ever increasing. In addition to cognitive …
the cost of health care associated with dementia is ever increasing. In addition to cognitive …
NMDA receptor regulation of memory and behavior in humans
JW Newcomer, JH Krystal - Hippocampus, 2001 - Wiley Online Library
Abstract N‐methyl‐D‐aspartate (NMDA) receptor hypofunction is associated with a range of
effects on cognition and behavior in whole animal and human studies. NMDA receptor …
effects on cognition and behavior in whole animal and human studies. NMDA receptor …
Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease
The cholinergic system is crucial for cognitive processes and the deficient acetylcholine
(ACh) function has been implicated in Alzheimer's disease (AD). Inhibitors of …
(ACh) function has been implicated in Alzheimer's disease (AD). Inhibitors of …
Deficits in N-methyl-D-aspartate receptor function and synaptic plasticity in hippocampal CA1 in APP/PS1 mouse model of Alzheimer's disease
L Xu, Y Zhou, L Hu, H Jiang, Y Dong, H Shen… - Frontiers in Aging …, 2021 - frontiersin.org
The N-methyl-D-aspartate receptor is a critical molecule for synaptic plasticity and cognitive
function. Impaired synaptic plasticity is thought to contribute to the cognitive impairment …
function. Impaired synaptic plasticity is thought to contribute to the cognitive impairment …
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals
A Kumar, A Rani, RB Scheinert, BK Ormerod… - Neurobiology of …, 2018 - Elsevier
A redox-mediated decrease in N-methyl-D-aspartate (NMDA) receptor function contributes
to psychiatric diseases and impaired cognition during aging. Inflammation provides a …
to psychiatric diseases and impaired cognition during aging. Inflammation provides a …
Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated …
Neuroinflammation plays a key role in the initiation and progression of neurodegeneration in
Alzheimer's disease (AD). Chronic neuroinflammation results in diminished synaptic …
Alzheimer's disease (AD). Chronic neuroinflammation results in diminished synaptic …
Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors
S Rosi, V Ramirez-Amaya, B Hauss-Wegrzyniak… - Journal of …, 2004 - Springer
Background Neuroinflammation plays a prominent role in the progression of Alzheimer's
disease and may be responsible for degeneration in vulnerable regions such as the …
disease and may be responsible for degeneration in vulnerable regions such as the …