Neuroprotective role for galanin in Alzheimer's disease

SE Counts, SE Perez, SD Ginsberg, EJ Mufson - Galanin, 2010 - Springer
Galanin (GAL) and GAL receptors (GALR) are overexpressed in degenerating brain regions
associated with cognitive decline in Alzheimer's disease (AD). The functional consequences …

Galanin–25 years with a multitalented neuropeptide: Galanin in Alzheimer's disease: Neuroinhibitory or neuroprotective?

SE Counts, SE Perez, EJ Mufson - Cellular and Molecular Life Sciences, 2008 - Springer
Galanin (GAL) and GAL receptors (GALRs) are overexpressed in degenerating brain
regions associated with cognitive decline in Alzheimer's disease (AD). The functional …

[HTML][HTML] Galanin in Alzheimer disease

SE Counts, SE Perez, SD Ginsberg… - Molecular …, 2003 - triggered.clockss.org
Galanin (GAL) and GAL receptors (GALR) are overexpressed in limbic brain regions
associated with cognition in Alzheimer disease (AD). The functional consequences of this …

Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease

SE Counts, SE Perez, U Kahl, T Bartfai… - CNS drug …, 2001 - Wiley Online Library
The neuropeptide galanin (GAL) is widely distributed in the mammalian CNS. Several lines
of evidence suggest that GAL may play a critical role in cognitive processes such as memory …

Endogenous galanin protects mouse hippocampal neurons against amyloid toxicity in vitro via activation of galanin receptor-2

CR Elliott-Hunt, FE Holmes, DM Hartley… - Journal of …, 2011 - content.iospress.com
Expression of the neuropeptide galanin is known to be upregulated in the brain of patients
with Alzheimer's disease (AD). We and others have shown that galanin plays a …

Galanin plasticity in the cholinergic basal forebrain in Alzheimer's disease and transgenic mice

EJ Mufson, SE Counts, SE Perez, L Binder - Neuropeptides, 2005 - Elsevier
Galanin (GAL) is a biologically active 29 amino acid (30 in humans) which participates in the
modulation of several ascending neurotransmitter systems including cholinergic basal …

Increased galanin receptor occupancy in Alzheimer's disease

PJ McMillan, E Peskind, MA Raskind, JB Leverenz - Neurobiology of aging, 2004 - Elsevier
Increased galanin (GAL) may be associated with the cognitive deficits characteristic of
Alzheimer's disease (AD). However, both increased and decreased GAL receptor density …

Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage

CR Elliott‐Hunt, RJP Pope… - Journal of …, 2007 - Wiley Online Library
Expression of the neuropeptide galanin is up‐regulated in many brain regions following
nerve injury and in the basal forebrain of patients with Alzheimer's disease. We have …

Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease

RA Steiner, JG Hohmann, A Holmes… - Proceedings of the …, 2001 - National Acad Sciences
Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and
memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate …

Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons

X Ding, D MacTavish, S Kar, JH Jhamandas - Neurobiology of disease, 2006 - Elsevier
In brains of Alzheimer's disease (AD) patients, expression of the neuropeptide galanin is
significantly upregulated and galanin-immunoreactive fibers hypertrophy and …