Context Young boys treated with high-dose chemotherapy are often confronted with infertility
once they reach adulthood. Cryopreserving testicular tissue before chemotherapy and …

OBJECTIVE: To evaluate colonizing ability of human spermatogonial stem cells in mouse
testes. DESIGN: Transplantation of human testis cells into the seminiferous tubules of …

Results. Two and a half weeks after initiation of the testicular cell culture, the first germline
stem cell (GSC) clusters appeared. Testicular cells were cultured for 20 and 15.5 weeks from …

Spermatogenesis occurs within the seminiferous tubules of mammals by a complex process
that is highly organized, extremely efficient and very productive. At the foundation of this …

The ability to isolate, manipulate, and transplant spermatogonial stem cells provides a
unique opportunity to modify the germline. We used the rat-to-nude mouse transplantation …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man's life and
may have application for treating some cases of male infertility, including those caused by …

Male germline stem cells—spermatogonial stem cells (SSCs)—self-renew and produce
large numbers of differentiating germ cells that become spermatozoa throughout postnatal …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Spermatogenesis is a complex process that originates in a small population of
spermatogonial stem cells. Here we report the in vitro culture of spermatogonial stem cells …

Mammalian male germ cells might be generally thought to have infinite proliferative potential
based on their life-long production of huge numbers of sperm. However, there has been little …