Stability and Kinetics of c-MYC Promoter G-Quadruplexes Studied by Single-Molecule Manipulation
A DNA G-quadruplex (G4) formed at the oncogene c-MYC promoter region functions as a
gene silencer. Due to its high stability at physiological K+ concentrations, its …
gene silencer. Due to its high stability at physiological K+ concentrations, its …
Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc …
E Hatzakis, K Okamoto, D Yang - Biochemistry, 2010 - ACS Publications
Overexpression of the c-Myc proto-oncogene is associated with a broad spectrum of human
cancers. Nuclease hypersensitivity element III1 (NHE III1) of the c-Myc promoter can form …
cancers. Nuclease hypersensitivity element III1 (NHE III1) of the c-Myc promoter can form …
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
A Siddiqui-Jain, CL Grand… - Proceedings of the …, 2002 - National Acad Sciences
The nuclease hypersensitivity element III1 upstream of the P1 promoter of c-MYC controls 85–
90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich …
90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich …
Distinguishing G-Quadruplexes Stabilizer and Chaperone for c-MYC Promoter G-Quadruplexes through Single-Molecule Manipulation
Y Zhang, Y Cheng, Q Luo, T Wu, J Huo… - Journal of the …, 2024 - ACS Publications
G-quadruplex (G4) selective stabilizing ligands can regulate c-MYC gene expression, but
the kinetic basis remains unclear. Determining the effects of ligands on c-MYC promoter …
the kinetic basis remains unclear. Determining the effects of ligands on c-MYC promoter …
c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex …
RI Mathad, E Hatzakis, J Dai, D Yang - Nucleic acids research, 2011 - academic.oup.com
We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region
containing the four consecutive 5′ runs of guanines of c-MYC promoter NHE III 1, which …
containing the four consecutive 5′ runs of guanines of c-MYC promoter NHE III 1, which …
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization
The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter strongly controls
the transcriptional activity of the c-MYC oncogene. The purine-rich strand of the NHE III1 …
the transcriptional activity of the c-MYC oncogene. The purine-rich strand of the NHE III1 …
Solution structure of a 2: 1 quindoline–c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design
Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
J Dickerhoff, J Dai, D Yang - Nucleic Acids Research, 2021 - academic.oup.com
Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
R Chaudhuri, S Bhattacharya, J Dash… - Journal of Medicinal …, 2020 - ACS Publications
Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
Effects of salt on the stability of a G-quadruplex from the human c-MYC promoter
BG Kim, HM Evans, DN Dubins, TV Chalikian - Biochemistry, 2015 - ACS Publications
In an atmosphere of potassium ions, a modified c-MYC NHE III1 sequence with two G-to-T
mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded G-quadruplex. The G …
mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded G-quadruplex. The G …