Metabotropic glutamate (mGlu) receptors are expressed throughout the central nervous
system and act as important regulators of drug-induced neuroplasticity and behavior …

Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics
registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been …

Methamphetamine abuse leads to devastating consequences, including addiction, crime,
and death. Despite decades of research, no medication has been approved by the US Food …

Group II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors) shape
mechanisms of methamphetamine addiction, but the individual role played by the two …

Addiction to drugs of abuse is a disorder that involves dysfunctions in motivational
processes. Both the primary rewarding effects of drugs, as well as the acquired motivational …

Addiction to methamphetamine is a significant public health problem, and there are currently
no pharmacological agents that are approved for the treatment of addiction to this powerful …

Drug addiction is characterized by drug-induced positive affect, followed by withdrawal-
associated negative affect. Such drug-induced positive and negative affective states provide …

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system
that guides developmental and experience-dependent changes in many cellular substrates …

Rationale Metabotropic glutamate (mGlu) receptors have been suggested to play a role in
neuropsychiatric disorders including schizophrenia, drug abuse, and depression. Because …

Brain glutamate has been shown to play an important role in reinstatement to drug seeking,
a behavior considered to be of relevance to relapse to drug taking in humans. Therefore …