This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

The bioavailability of drugs from oral formulations is influenced by many physiological
factors including gastrointestinal fluid composition, pH and dynamics, transit and motility …

Most marketed drugs are administered orally, despite the complex process of oral
absorption that is difficult to predict. Oral bioavailability is dependent on the interplay …

The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …

Our knowledge of the major mechanisms underlying the effect of food on drug absorption
allows reliable qualitative prediction based on biopharmaceutical properties, which can be …

Drugs are absorbed after oral administration as a consequence of a complex array of
interactions between the drug, its formulation, and the gastrointestinal (GI) tract. The …

Modeling and simulation of oral drug absorption have been widely used in drug discovery,
development, and regulation. Predictive absorption models are used to determine the rate …

This article provides an overview of the patient‐specific and drug‐specific variables that can
affect drug absorption following oral product administration. The oral absorption of any …

Comprehensive models of oral drug absorption which allow direct extrapolation to humans
from in vitro measured data have the potential to provide tremendous benefits to the …

Although several routes of administration can be considered for new drug entities, the oral
route remains the most popular. To predict the in vivo performance of a drug after oral …