Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …

Cardiac fibrosis is a common pathological change associated with cardiac injuries and
diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

The cardiac extracellular matrix (ECM) is a dynamic structure, adapting to physiological and
pathological stresses placed on the myocardium. Deposition and organization of the matrix …