Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration
into the central nervous system leading to inflammation, demyelination, and neuronal loss …

Th17 cells have been casually associated to the pathogenesis of autoimmune disease. We
have previously demonstrated that Rai/ShcC, a member of the Shc family of adaptor …

Astrocytes are highly heterogeneous in their phenotype and function, which contributes to
CNS disease, repair, and aging; however, the molecular mechanism of their functional …

Neuropathology in the human autoimmune disease multiple sclerosis (MS) is considered to
be mediated by autoreactive leukocytes, such as T cells, B cells, and macrophages …

Reactive astrocytes are a hallmark of neurodegenerative disease including multiple
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …

Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …

Multiple sclerosis is a neurologic disease caused by immune cell infiltration into the central
nervous system, resulting in gray and white matter inflammation, progressive demyelination …

Astrocytes are the first cells that are encountered by T cells invading the central nervous
system (CNS) by crossing the blood-brain barrier. We show that primary astrocytes …

Interaction between autoreactive immune cells and astroglia is an important part of the
pathologic processes that fuel neurodegeneration in multiple sclerosis. In this inflammatory …

Astrocytes have many functions in the central nervous system (CNS). They support
differentiation and homeostasis of neurons and influence synaptic activity. They are …