Environmental pollutants and phosphoinositide signaling in autoimmunity

C Ren, ND Carrillo, VL Cryns, RA Anderson… - Journal of Hazardous …, 2023 - Elsevier
Environmental pollution stands as one of the most critical challenges affecting human
health, with an estimated mortality rate linked to pollution-induced non-communicable …

Environmental agents, oxidative stress and autoimmunity

MF Khan, G Wang - Current opinion in toxicology, 2018 - Elsevier
Oxidative stress (OS) plays an important role in the pathogenesis of a variety of autoimmune
diseases (ADs) and many environmental agents participate in this process. Environmental …

Requirements for innate immune pathways in environmentally induced autoimmunity

KM Pollard, DH Kono - BMC medicine, 2013 - Springer
There is substantial evidence that environmental triggers in combination with genetic and
stochastic factors play an important role in spontaneous autoimmune disease. Although the …

Environmental contaminants and the immune system: A systems perspective

M Pinder, RC Fry, NE Alexis - … epigenetics in toxicology and public health, 2020 - Elsevier
The immune system is a critical responder to environmental toxicants, consequently immune
functionality is vitally tied to health and disease. Immune system dysfunction has the …

[HTML][HTML] Exposure to environmental toxins and autoimmune conditions

D Kharrazian - Integrative Medicine: A Clinician's Journal, 2021 - ncbi.nlm.nih.gov
The incidence of autoimmunity is growing rapidly worldwide. Many epidemiological studies
have found environmental factors, such as toxic chemicals (persistent organic pollutants …

[HTML][HTML] The role of the environment in autoimmunity

JJ Pestka, KM Pollard, AJ Rosenspire - Frontiers in Immunology, 2021 - frontiersin.org
Preclinical and epidemiologic investigations reveal that environmental factors may impact
multiple immune system checkpoints within the framework of an individual's unique genetics …

Emerging role of air pollution in autoimmune diseases

CN Zhao, Z Xu, GC Wu, YM Mao, LN Liu, YL Dan… - Autoimmunity …, 2019 - Elsevier
Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's
immune responses being directed against its own tissues, resulting in prolonged …

[HTML][HTML] Differential impact of environmental factors on systemic and localized autoimmunity

H Touil, K Mounts, PL De Jager - Frontiers in immunology, 2023 - frontiersin.org
The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …

Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration

SE Gomez-Mejiba, Z Zhai, H Akram, QN Pye… - … /genetic toxicology and …, 2009 - Elsevier
Human life expectancy and welfare has decreased because of the increase in
environmental stressors in the air. An environmental stressor is a natural or human-made …

UV radiation and air pollution as drivers of major autoimmune conditions

D Piovani, E Brunetta, S Bonovas - Environmental Research, 2023 - Elsevier
Autoimmune diseases comprise a very heterogeneous group of disorders characterized by
disruptive immune responses against self-antigens, chronic morbidity and increased …