RESPIRE 1: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis

A De Soyza, T Aksamit, TJ Bandel… - European …, 2018 - Eur Respiratory Soc
We evaluated the efficacy and safety of ciprofloxacin dry powder for inhalation (DPI) in
patients with non-cystic fibrosis bronchiectasis, two or more exacerbations in the previous …

RESPIRE 2: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis

T Aksamit, A De Soyza, TJ Bandel… - European …, 2018 - Eur Respiratory Soc
We evaluated the efficacy and safety of ciprofloxacin dry powder for inhalation (DPI) in
patients with non-cystic fibrosis bronchiectasis, two or more exacerbations in the previous …

Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study

R Wilson, T Welte, E Polverino… - European …, 2013 - Eur Respiratory Soc
This phase II, randomised, double-blind, multicentre study (NCT00930982) investigated the
safety and efficacy of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic …

[HTML][HTML] Tolerability and pharmacokinetic properties of ciprofloxacin dry powder for inhalation in patients with cystic fibrosis: a phase I, randomized, dose-escalation …

H Stass, B Weimann, J Nagelschmitz… - Clinical …, 2013 - Elsevier
Background Inhaled antibacterial agents are used to manage chronic pulmonary infections
in cystic fibrosis (CF) and non-CF bronchiectasis. However, established nebulized …

Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): a randomised, double-blind, placebo-controlled trial

DJ Serisier, D Bilton, A De Soyza, PJ Thompson… - Thorax, 2013 - thorax.bmj.com
Background The delivery of antipseudomonal antibiotics by inhalation to Pseudomonas
aeruginosa-infected subjects with non-cystic fibrosis (CF) bronchiectasis is a logical …

[HTML][HTML] Ciprofloxacin dry powder for inhalation (ciprofloxacin DPI): technical design and features of an efficient drug–device combination

PJ McShane, JG Weers, TE Tarara, A Haynes… - Pulmonary …, 2018 - Elsevier
Bronchiectasis is a chronic respiratory disease with heterogeneous etiology, characterized
by a cycle of bacterial infection and inflammation, resulting in increasing airway damage …

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4) …

CS Haworth, D Bilton, JD Chalmers… - The lancet Respiratory …, 2019 - thelancet.com
Background In patients with non-cystic fibrosis bronchiectasis, lung infection with
Pseudomonas aeruginosa is associated with frequent pulmonary exacerbations and …

Aerosolized antibiotics for non-cystic fibrosis bronchiectasis

BK Rubin - Journal of Aerosol Medicine and Pulmonary Drug …, 2008 - liebertpub.com
There are strong data supporting using the use of aerosolized antibiotics for the treatment of
Gram-negative infections in patients with cystic fibrosis (CF). The regular use of aerosol …

Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: a systematic review

AM Brodt, E Stovold, L Zhang - European Respiratory Journal, 2014 - Eur Respiratory Soc
We conducted a meta-analysis of randomised trials to evaluate the efficacy and safety of
inhaled antibiotics in patients with stable non-cystic fibrosis (CF) bronchiectasis. We …

Efficacy and safety of long‐term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta‐analysis

JW Yang, LC Fan, HW Lu, XY Miao… - The clinical …, 2016 - Wiley Online Library
Abstract Background and Aims The evidence supported the use of nebulized antibiotics in
non‐cystic fibrosis (non‐CF) bronchiectasis is indefinite. A meta‐analysis was performed to …