The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

Asthma is a heterogeneous disease characterized by numerous phenotypes relating to age
of onset, triggers, comorbidities, severity (assessed by multiple exacerbations, lung function …

Childhood asthma represents a heterogeneous challenging disease, in particular in its
severe forms. The identification of different asthma phenotypes has stimulated research in …

In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory
response to early life exposures or events. Interactions between infections, atopy, genetic …

In this review, we aim to lead the readers through the historical highlights of
pathophysiological concepts and treatment of asthma. Understanding the nature and links of …

Asthma is the most common chronic pediatric lung disease that has traditionally been
defined as a syndrome of airway inflammation characterized by clinical symptoms of cough …

The hallmark pathological features of asthma include airway eosinophilic inflammation and
structural changes (remodelling) which are associated with an irreversible loss in lung …

Guidelines for the management of severe asthma do not emphasize the measurement of the
inflammatory component of airway disease to indicate appropriate treatments or to monitor …

Although the hallmark features of asthma include reversible airflow obstruction, airway
eosinophilia, and symptoms of recurrent wheeze associated with breathlessness and cough …

Childhood asthma remains a multifactorial disease with heterogeneous clinical phenotype
and complex genetic inheritance. The primary aim of asthma management is to achieve …