The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
The cell-cell adhesion molecule E-cadherin
F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
P-cadherin linking breast cancer stem cells and invasion: a promising marker to identify an “intermediate/metastable” EMT state
AS Ribeiro, J Paredes - Frontiers in oncology, 2015 - frontiersin.org
Epithelial–mesenchymal transition (also known as EMT) is a fundamental mechanism
occurring during embryonic development and tissue differentiation, being also crucial for …
occurring during embryonic development and tissue differentiation, being also crucial for …
Epithelial-to-mesenchymal transition in tumor progression
E Prieto-García, CV Díaz-García, I García-Ruiz… - Medical Oncology, 2017 - Springer
The epithelial-to-mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT …
epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT …
A guide and guard: the many faces of T-cadherin
Cadherins are a superfamily of transmembrane proteins that mediate calcium-dependent
intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member …
intercellular adhesion. T-cadherin (T-cad, H-cadherin or cadherin-13) is an atypical member …
A milestone in epithelial–mesenchymal transition
Y Sun, L Ma - Nature cell biology, 2024 - nature.com
Epithelial–mesenchymal transition (EMT) is crucial in embryogenesis and can be exploited
by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000 …
by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000 …
N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility
JB Kim, S Islam, YJ Kim, RS Prudoff, KM Sass… - The Journal of cell …, 2000 - rupress.org
E-and N-cadherin are members of the classical cadherin family of proteins. E-cadherin plays
an important role in maintaining the normal phenotype of epithelial cells. Previous studies …
an important role in maintaining the normal phenotype of epithelial cells. Previous studies …
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
SJ Serrano-Gomez, M Maziveyi, SK Alahari - Molecular cancer, 2016 - Springer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
Cadherin switch in tumor progression
RB Hazan, RUI Qiao, R Keren… - Annals of the New …, 2004 - Wiley Online Library
The loss of E‐cadherin expression or function in epithelial carcinomas has long been
thought as a primary reason for disruption of tight epithelial cell‐cell contacts and release of …
thought as a primary reason for disruption of tight epithelial cell‐cell contacts and release of …
Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis
The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell
polarity and loss of expression of the cell-cell adhesion molecule like E-cadherin and …
polarity and loss of expression of the cell-cell adhesion molecule like E-cadherin and …