Gingival mesenchymal stem cells attenuate pro-inflammatory macrophages stimulated with oxidized low-density lipoprotein and modulate lipid metabolism

R Hong, Z Wang, A Sui, X Liu, C Fan, S Lipkind… - Archives of Oral …, 2019 - Elsevier
Objective To examine the effects of gingival mesenchymal stem cells (GMSCs) on
inflammatory macrophages upon oxidized low-density lipoprotein (ox-LDL) stimulation and …

Systematically transplanted human gingiva‑derived mesenchymal stem cells regulate lipid metabolism and inflammation in hyperlipidemic mice with periodontitis

X Liu, Z Wang, W Song, W Sun… - Experimental and …, 2020 - spandidos-publications.com
Gingiva‑derived mesenchymal stem cells (GMSCs) have been the focus of extensive
research due to their numerous distinct properties, including their homing to injury sites and …

Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis

X Zhang, F Huang, W Li, J Dang, J Yuan… - Frontiers in …, 2018 - frontiersin.org
Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate
that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived …

Porphyromonas gingivalis lipopolysaccharides regulate functions of bone marrow mesenchymal stem cells

J Tang, T Wu, J Xiong, Y Su, C Zhang, S Wang… - Cell …, 2015 - Wiley Online Library
Objectives Periodontitis is one of the most widespread inflammatory diseases; it causes
tooth loss and is also associated with a variety of systemic diseases. Mesenchymal stem …

Anti‐apoptotic effects of human gingival mesenchymal stromal cells on polymorphonuclear leucocytes

A Blufstein, C Behm, B Kubin, J Gahn, A Moritz… - Oral …, 2022 - Wiley Online Library
Abstract Objectives Polymorphonuclear leucocytes (PMNs) constitute the first line of host
defence and are crucial in maintaining periodontal health. Their survival and function are …

Inflammatory environment induces gingival tissue‐specific mesenchymal stem cells to differentiate towards a pro‐fibrotic phenotype

N Li, N Liu, J Zhou, L Tang, B Ding, Y Duan… - Biology of the …, 2013 - Wiley Online Library
Abstract Background Information Human gingival tissues are prone to hyperplasia under
inflammatory stimuli. We have identified gingival tissue‐specific mesenchymal stem cells …

Characterization of mesenchymal stem cells from human normal and hyperplastic gingiva

L Tang, N Li, H Xie, Y Jin - Journal of cellular physiology, 2011 - Wiley Online Library
Human gingiva plays an important role in the maintenance of oral health and shows unique
fetal‐like scarless healing process after wounding. Here we isolate and characterize …

Mesenchymal Stromal Cells from Healthy and Inflamed Human Gingiva Respond Differently to Porphyromonas gingivalis

M Bekić, M Radanović, J Đokić, S Tomić… - International Journal of …, 2022 - mdpi.com
Gingiva-Derived Mesenchymal Stromal Cells (GMSCs) have been shown to play an
important role in periodontitis. However, how P. gingivalis, one of the key etiological agents …

Immunomodulatory properties of dental tissue‐derived mesenchymal stem cells

Z Li, CM Jiang, S An, Q Cheng, YF Huang… - Oral …, 2014 - Wiley Online Library
In addition to their well‐established self‐renewal and multipotent differentiation properties,
mesenchymal stem cells (MSC s) also possess potent immunomodulatory functions both in …

Response of human mesenchymal stromal cells from periodontal tissue to LPS depends on the purity but not on the LPS source

C Behm, A Blufstein, SY Abhari, C Koch… - Mediators of …, 2020 - Wiley Online Library
Human periodontal ligament stromal cells (hPDLSCs) and gingival mesenchymal stromal
cells (hGMSCs) are resident mesenchymal stromal cells (MSCs) of the periodontal tissue …